Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Aqp2tm1(cre)Blyg
Name:	aquaporin 2; targeted mutation 1, Baoli Yang
MGI ID:	MGI:3711456
Synonyms:	Aqpdelta230
Gene:	Aqp2  Location: Chr15:99476937-99482426 bp, + strand  Genetic Position: Chr15, 56.13 cM
Alliance:	Aqp2tm1(cre)Blyg page

Germline Transmission:	Earliest citation of germline transmission: J:121445
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Aqp2tm1(cre)Blyg expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aqp2 (MGI:1096865)   Mutation details: A targeting vector was designed to insert an IRES-cre-ER-neo into exon 4. This insertion resulted in the loss of the protein kinase A phosphorylation site (S256), but the putative apical localization signal remained. RT-PCR demonstrates no expression for the downstream segment of exon 4, however, transcript for the upstream portion including cre recombinase, was detected. (J:121445)

Activity:	Tissue activity of this recombinase allele
Driver:	Aqp2 (mouse) Summary of all recombinase alleles driven by Aqp2. Alliance mouse Aqp2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp2 Mutation:	17 strains or lines available

Original:	J:121445 Shi PP, et al., Nephrogenic diabetes insipidus in mice caused by deleting COOH-terminal tail of aquaporin-2. Am J Physiol Renal Physiol. 2007 May;292(5):F1334-44
All:	1 reference(s)