Hdac2<Gt(W035F03)Joe> Gene trapped Allele Detail MGI Mouse (MGI:3712002)

Hdac2^{Gt(W035F03)Joe}
Gene trapped Allele Detail

Summary

Symbol:	Hdac2^{Gt(W035F03)Joe}
Name:	histone deacetylase 2; gene trap W035F03, Jonathan A Epstein
MGI ID:	MGI:3712002
Synonyms:	Hdac2^-
Gene:	Hdac2 Location: Chr10:36850540-36877885 bp, + strand Genetic Position: Chr10, 19.44 cM, cytoband B1
Alliance:	Hdac2^{Gt(W035F03)Joe} page

Mutation
origin

Mutant Cell Line:	W035F03
Germline Transmission:	Earliest citation of germline transmission: J:121697
Parent Cell Line:	TBV2 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pT1betageo

Mutation details: A gene trap containing lacZ was inserted into intron 8 and removed exons 9-14, which encode portions of the catalyitic domain. Western blot demonstrated absence of protein from mutant embryos. (J:121697)

Sequence Tags:

Sequence tag details (1 tag)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background
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hm1	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}	involves: 129S2/SvPas
hm2	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}	Not Specified
cx3	Apc^Min/Apc⁺ Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe}	involves: 129S2/SvPas * C57BL/6J
cx4	Hdac2^{Gt(W035F03)Joe}/Hdac2^{Gt(W035F03)Joe} Tg(Myh6-Hod)3Joe/?	Not Specified

Phenotypes:

Affected Systems	hm1		hm2	cx3	cx4
show or hide all annotated terms Sex:
behavior/neurological			√
lethargy			√
cardiovascular system			√		√
cardiovascular system phenotype			N
abnormal cardiovascular system morphology			√
abnormal myocardium layer morphology			√
abnormal myocardial fiber morphology			√
abnormal myocardial trabeculae morphology			√
thick myocardium compact layer			√
enlarged heart			√		√
cardiac hypertrophy					√
thick ventricular wall			√
abnormal cardiovascular system physiology			√
increased fetal cardiomyocyte proliferation			√
cellular			√
increased fetal cardiomyocyte proliferation			√
digestive/alimentary system	√	√		√
abnormal intestinal mucosa morphology	√	√
abnormal large intestine crypts of Lieberkuhn morphology	√	√
decreased intestine length	√	√
increased small intestine adenocarcinoma incidence				√
endocrine/exocrine glands	√	√
abnormal large intestine crypts of Lieberkuhn morphology	√	√
small testis		√
growth/size/body	√	√	√		√
enlarged heart			√		√
cardiac hypertrophy					√
decreased body size			√
decreased body weight	√	√
homeostasis/metabolism	√	√
insensitivity to growth hormone	√	√
mortality/aging	√	√	√
decreased survivor rate	√	√
postnatal lethality, incomplete penetrance			√
prenatal lethality, incomplete penetrance			√
embryonic lethality during organogenesis, incomplete penetrance	√	√
muscle			√
abnormal myocardium layer morphology			√
abnormal myocardial fiber morphology			√
abnormal myocardial trabeculae morphology			√
thick myocardium compact layer			√
increased fetal cardiomyocyte proliferation			√
diffuse Z line			√
neoplasm				√
increased small intestine adenocarcinoma incidence				√
decreased tumor incidence				√
nervous system	√	√
decreased brain weight	√	√
reproductive system		√
small testis		√
skeleton	√	√
abnormal pelvic girdle bone morphology	√	√
small vertebrae	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	27 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hdac2 Mutation:	40 strains or lines available

References

Original:	J:121697 Trivedi CM, et al., Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31
All:	7 reference(s)

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