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Pygo2tm1.2Ssp
Targeted Allele Detail
Summary
Symbol: Pygo2tm1.2Ssp
Name: pygopus 2; targeted mutation 1.2, S Steven Potter
MGI ID: MGI:3712856
Synonyms: Pygo2-
Gene: Pygo2  Location: Chr3:89337521-89342435 bp, + strand  Genetic Position: Chr3, 39.12 cM
Alliance: Pygo2tm1.2Ssp page
Small size, eye defects and exencephaly in Pygo1tm1.1Ssp/Pygo1tm1.1Ssp Pygo2tm1.2Ssp/Pygo2tm1.2Ssp mice at E18.5

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121918
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: A targeting contruct was designed to insert loxP sites to flank exon 3, containing the PHD motif. Crossing with mice expressing cre recombinase in the germline removed exon 3 from the locus. (J:121918)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pygo2 Mutation:  24 strains or lines available
References
Original:  J:121918 Schwab KR, et al., Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol. 2007;5:15
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory