Nfix<tm1Aes> Targeted Allele Detail MGI Mouse (MGI:3714028)

Nfix^tm1Aes
Targeted Allele Detail

Summary

Symbol:	Nfix^tm1Aes
Name:	nuclear factor I/X; targeted mutation 1, Albrecht E Sippel
MGI ID:	MGI:3714028
Synonyms:	Nfix^-, Nfix^lacZ
Gene:	Nfix Location: Chr8:85431341-85527086 bp, - strand Genetic Position: Chr8, 41.02 cM, cytoband C1-C2
Alliance:	Nfix^tm1Aes page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:122250
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A targeting vector was designed to replace all but the first 4 bp of exon 2 with a lacZ-loxP-neo-loxP cassette. Transient cre expression removed the neo in ES cells. RT-PCR confirmed absence of transcript in mutant brain, liver and lung samples. (J:122250)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Nfix Mutation:	61 strains or lines available

References

Original:	J:122250 Driller K, et al., Nuclear factor I X deficiency causes brain malformation and severe skeletal defects. Mol Cell Biol. 2007 May;27(10):3855-3867
All:	2 reference(s)

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