Maml1<tm1Mkit> Targeted Allele Detail MGI Mouse (MGI:3714162)

Maml1^tm1Mkit
Targeted Allele Detail

Summary

Symbol:	Maml1^tm1Mkit
Name:	mastermind like transcriptional coactivator 1; targeted mutation 1, Motoo Kitagawa
MGI ID:	MGI:3714162
Synonyms:	Mam1^-
Gene:	Maml1 Location: Chr11:50146461-50183138 bp, - strand Genetic Position: Chr11, 30.42 cM
Alliance:	Maml1^tm1Mkit page

Maml1^tm1Mkit/Maml1^tm1Mkit mice are growth retarded

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:122286
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 1 was replaced with a neomycin resistance cassette. This exon contains the ATG and enncodes the basic domain of the protein. (J:122286)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Maml1 Mutation:	26 strains or lines available

References

Original:	J:122286 Oyama T, et al., Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9764-9
All:	4 reference(s)

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