Dp(16Lipi-Zbtb21)1Yey Targeted Allele Detail MGI Mouse (MGI:3714529)

Dp(16Lipi-Zbtb21)1Yey
Targeted Allele Detail

Summary

Symbol:	Dp(16Lipi-Zbtb21)1Yey
Name:	duplication, Chr 16, Y Eugene Yu 1
MGI ID:	MGI:3714529
Synonyms:	Dp16, Dp(16)1/Yey, Dp(16)1Yey, Dp(16)1Yu, Dp(16D930038D03Tik-Zfp295)1Yey, Dp(16Lipi-Zfp295)1Yey, Dp1Yu, Ts1Yey
Gene:	Dp(16Lipi-Zbtb21)1Yey Location: unknown Genetic Position: Chr16, Syntenic

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:121790
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Inserted expressed sequence)
Mutation:		Duplication
		Dp(16Lipi-Zbtb21)1Yey involves 37 genes/genome features (Gm26170, Gm26219, Gm15954 ...) View all
		Mutation details: A 22.9Mb region of chromosome 16 that is syntenic with human chromosome 21 was duplicated using a Cre/loxP-mediated recombination system. This region, thought to be involved in Down Syndrome, contains 113 orthologues including all markers between and including D930038D03Rik (Lipi) and Zfp295 (Zbtb21). (J:121790)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

14 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Dp(16Lipi-Zbtb21)1Yey Mutation:	3 strains or lines available

References

Original:	J:121790 Li Z, et al., Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum Mol Genet. 2007 Jun 1;16(11):1359-66
All:	74 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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