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Hand2tm1Cse
Targeted Allele Detail
Summary
Symbol: Hand2tm1Cse
Name: heart and neural crest derivatives expressed 2; targeted mutation 1, Peter Cserjesi
MGI ID: MGI:3715149
Synonyms: Hand22F, Hand2loxP
Gene: Hand2  Location: Chr8:57774018-57777552 bp, + strand  Genetic Position: Chr8, 29.8 cM
Alliance: Hand2tm1Cse page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122604
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: LoxP sites were inserted to flank the exon. A frt-flanked neo was included upstream of the 3' loxP site. Frt-mediated recombination removed the neo, leaving the single exon floxed. (J:122604)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hand2 Mutation:  12 strains or lines available
References
Original:  J:122604 Morikawa Y, et al., Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol. 2007 Jul 1;307(1):114-26
All:  14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory