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Pdyntm1(cre)Czer
Targeted Allele Detail
Summary
Symbol: Pdyntm1(cre)Czer
Name: prodynorphin; targeted mutation 1, Christoph Schwarzer
MGI ID: MGI:3715202
Synonyms: Dyn-
Gene: Pdyn  Location: Chr2:129528485-129541764 bp, - strand  Genetic Position: Chr2, 63.19 cM
Alliance: Pdyntm1(cre)Czer page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122651
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Pdyntm1(cre)Czer expression driven by 1 gene
 
Mutation details: The coding sequence for the transactivator of the Tet-on system (rTetR) was introduced directly after the ATG, disrupting the coding sequence. The transactivator responsive element (TRE) was placed in the reverse orientation, driving cre expression. Floxed neomycin and zeocin resistance genes were included in the vector, also in reverse orientation. (J:122651)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdyn (mouse)
Summary of all recombinase alleles driven by Pdyn.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdyn Mutation:  20 strains or lines available
References
Original:  J:122651 Loacker S, et al., Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors. Brain. 2007 Apr;130(Pt 4):1017-28
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory