Mapk14<tm2Nbr> Targeted Allele Detail MGI Mouse (MGI:3715522)

Mapk14^tm2Nbr
Targeted Allele Detail

Summary

Symbol:	Mapk14^tm2Nbr
Name:	mitogen-activated protein kinase 14; targeted mutation 14, Angel R Nebreda
MGI ID:	MGI:3715522
Synonyms:	Mapk14^lox, p38alpha^FL
Gene:	Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
Alliance:	Mapk14^tm2Nbr page

Developmental defects in Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca embryos

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:122397
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. The neo cassette was removed by germ line, flp mediated recombination. (J:122397, J:140566)

Generation of the Mapk14^{tm3.1(Mapk11)Nbr} allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:	43 strains or lines available

References

Original:	J:122397 Ventura JJ, et al., p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet. 2007 Jun;39(6):750-8
All:	27 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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