Mapk14<tm2Nbr> Targeted Allele Detail MGI Mouse (MGI:3715522)

Mapk14^tm2Nbr
Targeted Allele Detail

Summary

Symbol:	Mapk14^tm2Nbr
Name:	mitogen-activated protein kinase 14; targeted mutation 14, Angel R Nebreda
MGI ID:	MGI:3715522
Synonyms:	Mapk14^lox, p38alpha^FL
Gene:	Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
Alliance:	Mapk14^tm2Nbr page

Developmental defects in Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca embryos

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:122397
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 3. The neo cassette was removed by germ line, flp mediated recombination. (J:122397, J:140566)

Generation of the Mapk14^{tm3.1(Mapk11)Nbr} allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:	43 strains or lines available

References

Original:	J:122397 Ventura JJ, et al., p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet. 2007 Jun;39(6):750-8
All:	27 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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