Rpgrip1l<tm1Urt> Targeted Allele Detail MGI Mouse (MGI:3716208)

Rpgrip1l^tm1Urt
Targeted Allele Detail

Summary

Symbol:	Rpgrip1l^tm1Urt
Name:	Rpgrip1-like; targeted mutation 1, Ulrich Ruther
MGI ID:	MGI:3716208
Synonyms:	Ftm^-
Gene:	Rpgrip1l Location: Chr8:91943658-92039890 bp, - strand Genetic Position: Chr8, 44.29 cM
Alliance:	Rpgrip1l^tm1Urt page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:122745
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A targeted mutation was desgned to replace exons 4 and 5 with a PGK-neo cassette. The result was a truncated protein lacking all functional domains except the first coiled-coil domain. (J:122745)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Rpgrip1l Mutation:	58 strains or lines available

References

Original:	J:122745 Vierkotten J, et al., Ftm is a novel basal body protein of cilia involved in Shh signalling. Development. 2007 Jul;134(14):2569-77
All:	13 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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