Ar<tm1.1Jdz> Targeted Allele Detail MGI Mouse (MGI:3716756)

Ar^tm1.1Jdz
Targeted Allele Detail

Summary

Symbol:	Ar^tm1.1Jdz
Name:	androgen receptor; targeted mutation 1.1, Jeffrey D Zajac
MGI ID:	MGI:3716756
Synonyms:	AR^deltaZF2
Gene:	Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
Alliance:	Ar^tm1.1Jdz page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:123057
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: Cre-mediated recombination in the germline resulted in the loss of exon 3, which encodes the second zinc finger of the DNA-binding domain. This deletion has been designed to retain the normal reading frame so that the mutant AR can bind ligand but is unable to bind DNA and regulate target gene transcription. (J:123057)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ar Mutation:	23 strains or lines available

References

Original:	J:123057 Notini AJ, et al., Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model. J Mol Endocrinol. 2005 Dec;35(3):547-55
All:	13 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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