Tctn1<Gt(KST296)Byg> Gene trapped Allele Detail MGI Mouse (MGI:3716885)

Tctn1^{Gt(KST296)Byg}
Gene trapped Allele Detail

Summary

Symbol:	Tctn1^{Gt(KST296)Byg}
Name:	tectonic family member 1; gene trap KST296, BayGenomics
MGI ID:	MGI:3716885
Gene:	Tctn1 Location: Chr5:122377558-122402557 bp, - strand Genetic Position: Chr5, 62.25 cM
Alliance:	Tctn1^{Gt(KST296)Byg} page

Mutation
origin

Mutant Cell Line:	KST296
Germline Transmission:	Earliest citation of germline transmission: J:103820
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT1TMpfs Vector Type: secretory trap

Mutation details: A gene trap vector inserted into intron 1, resulting in a mutant allele containing the first 57 amino acids and a membrane-spanning betageo reporter. Wild-type transcript was shown to be absent in mutants by RT-PCR and Northern blot analyses. (J:103820)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Tctn1 Mutation:	33 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

Original:	J:103820 Reiter JF, et al., Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 1;20(1):22-7
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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