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Bsxtm1Aoh
Targeted Allele Detail
Summary
Symbol: Bsxtm1Aoh
Name: brain specific homeobox; targeted mutation 1, Akihira Ohtoshi
MGI ID: MGI:3719242
Synonyms: BsxdeltaHD
Gene: Bsx  Location: Chr9:40785423-40791353 bp, + strand  Genetic Position: Chr9, 21.65 cM
Alliance: Bsxtm1Aoh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:123638
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation details: A targeting vector containing a floxed neo cassette was inserted by homologous recombination in ES cells and subsequently removed by Cre mediated recombination upon tranmission from male chimeric mice, resulting in the deletion of the homeodomain. Targeting took place in ES cells that contain the Tg(Prm-cre)70Og transgene, which expresses Cre recombinase in male germ cells. Absence of endogenous transcript was confirmed by RT-PCR. (J:123638)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bsx Mutation:  19 strains or lines available
References
Original:  J:123638 McArthur T, et al., A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing. Mol Cell Biol. 2007 Jul;27(14):5120-7
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory