Siglec1<tm1(HBEGF)Mtka> Targeted Allele Detail MGI Mouse (MGI:3720841)

Siglec1^{tm1(HBEGF)Mtka}
Targeted Allele Detail

Summary

Symbol:	Siglec1^{tm1(HBEGF)Mtka}
Name:	sialic acid binding Ig-like lectin 1, sialoadhesin; targeted mutation 1, Masato Tanaka
MGI ID:	MGI:3720841
Synonyms:	CD169-DTR, CD169^DTR
Gene:	Siglec1 Location: Chr2:130911140-130928685 bp, - strand Genetic Position: Chr2, 63.26 cM, cytoband F-H1
Alliance:	Siglec1^{tm1(HBEGF)Mtka} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:123958
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:

Targeted (Inserted expressed sequence, Null/knockout)

Mutation:

Insertion

Siglec1^{tm1(HBEGF)Mtka} expresses 1 gene

Mutation details: A 28-bp fragment including the endogenous ATG in exon 1 was replaced with human heparin-binding EGF-like growth factor and a floxed neo cassette. (J:123958)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Siglec1 Mutation:	84 strains or lines available

References

Original:	J:123958 Miyake Y, et al., Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest. 2007 Aug;117(8):2268-78
All:	67 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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