Cbfbtm2Spe
Targeted Allele Detail
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| Symbol: |
Cbfbtm2Spe |
| Name: |
core binding factor beta; targeted mutation 2, Nancy A Speck |
| MGI ID: |
MGI:3721272 |
| Synonyms: |
Cbfbrss(neo) |
| Gene: |
Cbfb Location: Chr8:105897306-105944621 bp, + strand Genetic Position: Chr8, 53.04 cM
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| Alliance: |
Cbfbtm2Spe page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:124224
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: An extra copy of exon 4, interrupted by the lacZ coding sequence with a polyadenylation signal, has been inserted in reverse orientation upstream of the endogenous exon 4. A loxP-flanked neomycin resistance cassette (neo), in normal orientation, resides upstream of the reversed exon4-lacZ, separated from the latter by a V(D)J recombination signal sequence (RSS) with a 12-bp spacer. An RSS with a 23-bp spacer lies downstream of the endogenous exon 4.
(J:124224)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cbfb Mutation: |
36 strains or lines available
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| Original: |
J:124224 Talebian L, et al., T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood. 2007 Jan 1;109(1):11-21 |
| All: |
1 reference(s) |
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Analysis Tools
