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Tpsb2tm1(cre)Adch
Targeted Allele Detail
Summary
Symbol: Tpsb2tm1(cre)Adch
Name: tryptase beta 2; targeted mutation 1, Roberto Adachi
MGI ID: MGI:3722523
Synonyms: mMCP-6-
Gene: Tpsb2  Location: Chr17:25585282-25587070 bp, + strand  Genetic Position: Chr17, 12.53 cM, cytoband A3.3
Alliance: Tpsb2tm1(cre)Adch page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:124554
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129X1/SvJ x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Tpsb2tm1(cre)Adch expression driven by 1 gene
 
Mutation details: The three coding exons downstream of the translation initiation site was replaced with Cre recombinase cDNA. The remaining gene will lack critical amino acids including the codon that encodes the essential catalytic triad residue His75. Absence of wild type protein was confirmed by immunoblot. (J:124554)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tpsb2 (mouse)
Summary of all recombinase alleles driven by Tpsb2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpsb2 Mutation:  12 strains or lines available
References
Original:  J:124554 Thakurdas SM, et al., The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections. J Biol Chem. 2007 Jul 20;282(29):20809-15
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory