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Fosl2tm2.1Wag
Targeted Allele Detail
Summary
Symbol: Fosl2tm2.1Wag
Name: fos-like antigen 2; targeted mutation 2.1, Erwin F Wagner
MGI ID: MGI:3757560
Synonyms: Fosl-2-, fra-2delta
Gene: Fosl2  Location: Chr5:32293145-32315186 bp, + strand  Genetic Position: Chr5, 17.33 cM
Alliance: Fosl2tm2.1Wag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125028
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Intragenic deletion
 
Mutation details: ES cell containing Fosl2tm2Wag were transfected with a cre-expressing plasmid to remove the exons 3 and 4 along with a neo cassette. RNase protection and western blot were used to confirm the absence of full-length protein from mouse embryonic fibroblasts using an anti-Fosl2 antibody. However, a fusion protein with the remaining GFP open reading frame is detected using an anti-GFP antibody. (J:125028)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fosl2 Mutation:  13 strains or lines available
References
Original:  J:125028 Eferl R, et al., Simultaneous generation of fra-2 conditional and fra-2 knock-out mice. Genesis. 2007 Jul;45(7):447-51
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory