Fosl2tm2.1Wag
Targeted Allele Detail
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| Symbol: |
Fosl2tm2.1Wag |
| Name: |
fos-like antigen 2; targeted mutation 2.1, Erwin F Wagner |
| MGI ID: |
MGI:3757560 |
| Synonyms: |
Fosl-2-, fra-2delta |
| Gene: |
Fosl2 Location: Chr5:32293145-32315186 bp, + strand Genetic Position: Chr5, 17.33 cM
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| Alliance: |
Fosl2tm2.1Wag page
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutation: |
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Intragenic deletion
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Mutation details: ES cell containing Fosl2tm2Wag were transfected with a cre-expressing plasmid to remove the exons 3 and 4 along with a neo cassette. RNase protection and western blot were used to confirm the absence of full-length protein from mouse embryonic fibroblasts using an anti-Fosl2 antibody. However, a fusion protein with the remaining GFP open reading frame is detected using an anti-GFP antibody.
(J:125028)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129P2/OlaHsd | | | | involves: 129P2/OlaHsd * C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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cellular
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abnormal osteoclast differentiation
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growth/size/body
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decreased body size
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postnatal growth retardation
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hematopoietic system
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abnormal osteoclast morphology
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√
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abnormal osteoclast differentiation
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√
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increased osteoclast cell number
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abnormal osteoclast physiology
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homeostasis/metabolism
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hypoxia
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immune system
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abnormal osteoclast morphology
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√
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abnormal osteoclast differentiation
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√
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increased osteoclast cell number
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√
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abnormal osteoclast physiology
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mortality/aging
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postnatal lethality, complete penetrance
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√
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skeleton
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√
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abnormal osteoclast morphology
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√
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abnormal osteoclast differentiation
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√
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increased osteoclast cell number
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√
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abnormal osteoclast physiology
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√
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decreased bone mineral density
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√
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increased bone resorption
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fosl2 Mutation: |
13 strains or lines available
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| Original: |
J:125028 Eferl R, et al., Simultaneous generation of fra-2 conditional and fra-2 knock-out mice. Genesis. 2007 Jul;45(7):447-51 |
| All: |
8 reference(s) |
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Analysis Tools
