Gnptab<Gt(OST97730)Lex> Gene trapped Allele Detail MGI Mouse (MGI:3757945)

Gnptab^{Gt(OST97730)Lex}
Gene trapped Allele Detail

Summary

Symbol:	Gnptab^{Gt(OST97730)Lex}
Name:	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; gene trap OST97730, Lexicon Genetics
MGI ID:	MGI:3757945
Synonyms:	Gnptab^-
Gene:	Gnptab Location: Chr10:88215130-88283186 bp, + strand Genetic Position: Chr10, 43.86 cM
Alliance:	Gnptab^{Gt(OST97730)Lex} page

Mutation
origin

Mutant Cell Line:	OST97730
Germline Transmission:	Earliest citation of germline transmission: J:124928
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Mutation
description

Allele Type:

Gene trapped (Null/knockout)

Mutation:

Insertion of gene trap vector

Mutation details: The gene trap vector VICTR48 was inserted into the first intron, disrupting translation and resulting in a truncation of the alpha/beta precursor after 39 amino acids in the encoded protein. (J:124928)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gnptab Mutation:	78 strains or lines available

References

Original:	J:124928 Lee WS, et al., Murine UDP-GlcNAc:Lysosomal Enzyme N-Acetylglucosamine-1-phosphotransferase Lacking the {gamma}-Subunit Retains Substantial Activity toward Acid Hydrolases. J Biol Chem. 2007 Sep 14;282(37):27198-203
All:	12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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