Tg(dlx5a-cre)1Mekk Transgene Detail MGI Mouse (MGI:3758328)

Tg(dlx5a-cre)1Mekk
Transgene Detail

Summary

Symbol:	Tg(dlx5a-cre)1Mekk
Name:	transgene insertion 1, Marc Ekker
MGI ID:	MGI:3758328
Synonyms:	Dlx5/6-Cre, Dlx5/6i-Cre, line 8561, Tg(dlx6a-cre)1Mars, Tg(dlx6a-cre)1Mekk
Transgene:	Tg(dlx5a-cre)1Mekk Location: unknown
Alliance:	Tg(dlx5a-cre)1Mekk page

Transgene
origin

Strain of Origin:

CD-1

Transgene
description

Transgene Type:

Transgenic (Recombinase)

Mutation:

Insertion

Tg(dlx5a-cre)1Mekk expression driven by 1 gene

Mutation details: A cre gene was placed under the control of the I56i and I56ii enhancer elements of zebrafish dlx5a and a 3.5kb genomic DNA fragment flanking the 5' region of the zebrafish dlx6a open reading frame and containing the 5'UTR. The dlx6a flanking region on its own cannot produce tissue specific expression but increases the activity of the enhancers to produce expression that recapitulate endogenous Dlx5 expression. Tissue specific expression was confirmed by test crosses to reporter mice strains, including Tg(ACTB-Bgeo/ALPP)1Lbe, Tg(ACTB-Bgeo/GFP)21Lbe and Gt(ROSA)26Sor^tm1Sor. (J:122066)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	dlx5a (zebrafish) Summary of all recombinase alleles driven by dlx5a. Comparative matrix view of recombinase activities Alliance zebrafish dlx5a gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

77 assay results
6 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

Original:	J:122066 Monory K, et al., The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 2006 Aug 17;51(4):455-66
All:	139 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24