Comptm1Mbri
Targeted Allele Detail
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| Symbol: |
Comptm1Mbri |
| Name: |
cartilage oligomeric matrix protein; targeted mutation 1, Michael Briggs |
| MGI ID: |
MGI:3758741 |
| Synonyms: |
p.Thr583Met COMP |
| Gene: |
Comp Location: Chr8:70826208-70834716 bp, + strand Genetic Position: Chr8, 34.15 cM
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| Alliance: |
Comptm1Mbri page
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| Allele Type: |
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Targeted (Humanized sequence) |
| Mutation: |
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Single point mutation
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Mutation details: A T583M mutation (ACA to ATG) was created in exon 16 using site-directed mutagenesis and then knocked into the open reading frame. A floxed neo cassette used for ES cell selection was removed by cre-mediated recombination via a cross to a deleter Cre line (not specified). Insertion of the point mutations was confirmed by sequencing exon 16 in ES cells. Comparable protein expression to wild-type was confirmed by western blot and RT-PCR of 3 week old growth plate cartilage.
(J:125086)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Comp Mutation: |
37 strains or lines available
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| Original: |
J:125086 Pirog-Garcia KA, et al., Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP. Hum Mol Genet. 2007 Sep 1;16(17):2072-88 |
| All: |
7 reference(s) |
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Analysis Tools
