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Tg(MMTV-Cyp21a1)1Ms
Transgene Detail
Summary
Symbol: Tg(MMTV-Cyp21a1)1Ms
Name: transgene insertion 1, National Institute of Genetics, Mishima, Japan
MGI ID: MGI:3759420
Synonyms: Tg(17MMUCyp21)1Ms
Transgene: Tg(MMTV-Cyp21a1)1Ms  Location: unknown  
Alliance: Tg(MMTV-Cyp21a1)1Ms page
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MMTV-Cyp21a1)1Ms expresses 1 gene
 
Mutation details: The transgene contains the mouse mammary tumor virus long terminal repeat (MMTV LTR) driving expression of cytochrome P450, family 21, subfamily a, polypeptide 1 (Cyp21a1) from a 3.9-kb genomic DNA segment containing the Cyp21a1 gene and ~700 kb of 5' flanking DNA isolated from a cosmid library of B10.A-H2/SgSnJMis genomic DNA. In this line, 7-10 copies of the transgene were estimated by Southern blot analysis to have integrated into a single site on Chr 17, approximately 10 cM from the endogenous Cyp21a1 gene. (J:20978)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:20978 Gotoh H, et al., Survival of steroid 21-hydroxylase-deficient mice without endogenous corticosteroids after neonatal treatment and genetic rescue by transgenesis as a model system for treatment of congenital adrenal hyperplasia in humans. Endocrinology. 1994 Oct;135(4):1470-6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
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