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Prox1tm3(cre/ERT2)Gco
Targeted Allele Detail
Summary
Symbol: Prox1tm3(cre/ERT2)Gco
Name: prospero homeobox 1; targeted mutation 3, Guillermo Oliver
MGI ID: MGI:3759501
Synonyms: Prox1CreER, Prox1-CreERT2, Prox-1CreERT2, Prox1ert2cre, Prox1tm3(cre/ERT2)Gco, Prox1tm3(cre/ESR1)Gco
Gene: Prox1  Location: Chr1:189850232-189902911 bp, - strand  Genetic Position: Chr1, 95.85 cM
Alliance: Prox1tm3(cre/ERT2)Gco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:125507
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Prox1tm3(cre/ERT2)Gco expression driven by 1 gene
 
Mutation details: A synthetic splice acceptor site, exons 3 and 4, and an IRES-cre/ERT2 cassette were inserted into intron 2 along with a neo and thymidine kinase cassettes. Insertion was confirmed by Southern blot analysis and through crosses with reporter lines. Expression of cre is tamoxifen inducible and recapitulates endogenous promoter activity specifically in the central nervous system, eye, liver, heart, branchial arches and lymphatic endothelial cells. (J:125507)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Prox1 (mouse)
Summary of all recombinase alleles driven by Prox1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prox1 Mutation:  43 strains or lines available
References
Original:  J:125507 Srinivasan RS, et al., Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature. Genes Dev. 2007 Oct 1;21(19):2422-2432
All:  74 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory