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Cdk2tm2Sgo
Targeted Allele Detail
Summary
Symbol: Cdk2tm2Sgo
Name: cyclin dependent kinase 2; targeted mutation 2, Sagrario Ortega
MGI ID: MGI:3759555
Synonyms: Cdk2loxneo
Gene: Cdk2  Location: Chr10:128533808-128540900 bp, - strand  Genetic Position: Chr10, 77.13 cM, cytoband D3
Alliance: Cdk2tm2Sgo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85230
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A neomycin resistance gene flanked by loxP sites was inserted into intron 3 while a third loxP site was inserted into intron 1. Insertion was confirmed by Southern blot analysis. (J:85230)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdk2 Mutation:  18 strains or lines available
References
Original:  J:85230 Ortega S, et al., Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet. 2003 Sep;35(1):25-31
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory