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Tg(CD207-cre)1Dhka
Transgene Detail
Summary
Symbol: Tg(CD207-cre)1Dhka
Name: transgene insertion 1, Daniel H Kaplan
MGI ID: MGI:3761645
Synonyms: huLangerinCretg+, Langerin-Cre, Tg(CD207-cre)1Mjsk
Transgene: Tg(CD207-cre)1Dhka  Location: unknown  
Alliance: Tg(CD207-cre)1Dhka page
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL/J)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(CD207-cre)1Dhka expression driven by 1 gene
 
Mutation details: A cre recombinase gene optimized for mammalian codon usage was inserted right after the ATG of exon 1 in a human BAC, which was then injected into oocytes. Insertion of the cre gene was confirmed by PCR on genomic DNA. Cre expression is restricted to all epidermis MHC-II+CD11c+ Langerhans cells but not other CD207 expressing cells. (J:126147)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: CD207 (human)
Summary of all recombinase alleles driven by CD207.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:126147 Kaplan DH, et al., Autocrine/paracrine TGF{beta}1 is required for the development of epidermal Langerhans cells. J Exp Med. 2007 Oct 29;204(11):2545-52
All:  24 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory