Tg(KRT14-Il1f6)1Hblu Transgene Detail MGI Mouse (MGI:3762035)

Tg(KRT14-Il1f6)1Hblu
Transgene Detail

Summary

Symbol:	Tg(KRT14-Il1f6)1Hblu
Name:	transgene insertion 1, Hal Blumberg
MGI ID:	MGI:3762035
Transgene:	Tg(KRT14-Il1f6)1Hblu Location: unknown
Alliance:	Tg(KRT14-Il1f6)1Hblu page

Transgene
origin

Strain of Origin:

(C57BL/6 x DBA/2)F2

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(KRT14-Il1f6)1Hblu expresses 1 gene

Mutation details: The promoter of human KRT14 drives the expression of mouse Il1f5 in basal keratinocytes. At least 70-fold higher mRNA expression compared to in wild-type was detected in mice expressing this transgene. (J:126327)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

9 founders were used to create 4 lines with at least 70-fold higher mRNA expression.

References

Original:	J:126327 Blumberg H, et al., Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J Exp Med. 2007 Oct 29;204(11):2603-14
All:	2 reference(s)

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