Krt75tm1Der
Targeted Allele Detail
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| Symbol: |
Krt75tm1Der |
| Name: |
keratin 75; targeted mutation 1, Dennis R Roop |
| MGI ID: |
MGI:3762626 |
| Gene: |
Krt75 Location: Chr15:101471780-101482339 bp, - strand Genetic Position: Chr15, 56.91 cM
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| Alliance: |
Krt75tm1Der page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:127018
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| Parent Cell Line: |
W4 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Dominant negative, Humanized sequence) |
| Mutation: |
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Intragenic deletion
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Mutation details: Exon 1 was replaced with a version of exon 1 in which the asparagine at position 159 was deleted. A floxed cre cassette that was inserted downstream of exon 1 for selection purposes was removed by cre-mediated recombination using a transient cre expressing plasmid. The authors state that this mutation should produce a dominant negative protein. Expression of only the modified transcript was confirmed by RT-PCR analysis.
(J:127018)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Krt75 Mutation: |
28 strains or lines available
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| Original: |
J:127018 Chen J, et al., Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling Pachyonychia Congenita. J Invest Dermatol. 2008 Feb;128(2):270-9 |
| All: |
4 reference(s) |
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Analysis Tools
