Gt(ROSA)26Sor<tm9(cre/ESR1)Arte> Targeted Allele Detail MGI Mouse (MGI:3763211)

Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}
Targeted Allele Detail

Summary

Symbol:	Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 9, TaconicArtemis
MGI ID:	MGI:3763211
Synonyms:	CreER^T2, Ert2-Cre, Gt(ROSA)26Sor^{tm1(cre/ESR1)Arte}, Gt(ROSA)26Sor^{tm9(Cre/ESR1)Arte}CreER^T2, RCE, Rosa26CreER^T2, rosa26(SA-CreERT2)ARTE, Rosa(CreER⁺), rosa(CreER^T2), rosa(SAcreER^T2)
Gene:	Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:126518
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} expression driven by 1 gene

Mutation details: A fusion protein consisting of cre recombinase and the mutated ligand binding domain of the human estrogen receptor (ERT2) was inserted into intron 1. The estrogen receptor contains 3 mutations (G400V, M543A, L544A) that increase sensitivity to tamoxifen. (J:126518)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	993 strains or lines available

References

Original:	J:126518 Seibler J, et al., Rapid generation of inducible mouse mutants. Nucleic Acids Res. 2003 Feb 15;31(4):e12
All:	211 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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