Egfrtm1Msi
Targeted Allele Detail
|
|
| Symbol: |
Egfrtm1Msi |
| Name: |
epidermal growth factor receptor; targeted mutation 1, Maria Sibilia |
| MGI ID: |
MGI:3763534 |
| Synonyms: |
EGFRf |
| Gene: |
Egfr Location: Chr11:16702203-16868158 bp, + strand Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
|
| Alliance: |
Egfrtm1Msi page
|
|
|
|
| Allele Type: |
|
Targeted (Conditional ready, No functional change) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: A targeting vector in which the promoter and the first exon of the gene are flanked by loxP sites was constructed. The upstream loxP site with a diagnostic XmaCI restriction site was placed into a BSMI site, and the downstream loxP site was cloned into the SexA1 site. A frt-flanked neomycin cassette was placed between exon 1 and the downstream loxP site. Recombination was confirmed through PCR and Southern blot analysis.
(J:125912)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Egfr Mutation: |
87 strains or lines available
|
|
| Original: |
J:125912 Natarajan A, et al., The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17081-6 |
| All: |
25 reference(s) |
|
Analysis Tools
