Gt(ROSA)26Sor<tm2.1(Mirn150)Rsky> Targeted Allele Detail MGI Mouse (MGI:3763537)

Gt(ROSA)26Sor^{tm2.1(Mirn150)Rsky}
Targeted Allele Detail

Summary

Symbol:	Gt(ROSA)26Sor^{tm2.1(Mirn150)Rsky}
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Klaus Rajewsky
MGI ID:	MGI:3763537
Synonyms:	Gt(ROSA)26Sor^{tm2.1(Mir150)Rsky}, mir150 Tg
Gene:	Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sor^{tm2.1(Mirn150)Rsky} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:127234
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Inserted expressed sequence)

Mutation:

Insertion

Gt(ROSA)26Sor^{tm2.1(Mirn150)Rsky} expresses 1 gene

Mutation details: Gt(ROSA)26Sor^{tm2(Mirn150)Rsky} mice were crossed to Tg(ACTFLPe)9205Dym mice to excise the frt-flanked IRES-EGFP cassette, producing mice slightly over-expressing Mirn150 (from the CAG promoter) in thymocytes. It is also possible to generate this allele from allele Gt(ROSA)26Sor^{tm14.1(Mirn150)Rsky}. (J:127234)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	992 strains or lines available

Notes

ES cell line = R19 (ARF1 R19 ES cells from Artemis Pharmaceuticals, Germany).

References

Original:	J:127234 Xiao C, et al., MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007 Oct 5;131(1):146-59
All:	3 reference(s)

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