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Ctsktm1(cre)Ska
Targeted Allele Detail
Summary
Symbol: Ctsktm1(cre)Ska
Name: cathepsin K; targeted mutation 1, Shigeaki Kato
MGI ID: MGI:3764465
Synonyms: Cathepsin K-Cre, CatKCre, CtskCre, CtsKCre
Gene: Ctsk  Location: Chr3:95406567-95416673 bp, + strand  Genetic Position: Chr3, 40.74 cM
Alliance: Ctsktm1(cre)Ska page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127179
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Ctsktm1(cre)Ska expression driven by 1 gene
 
Mutation details: A cre recombinase gene and a downstream frt-flanked kanamycin/neomycin resistance gene was inserted into the endogenous ATG start site of the gene, replacing the first four exons. Chimeric mice were crossed with a deleter strain to remove the selection cassette. Cre expression in heterozygotes was detected in mature osteoclasts but not osteoblasts when crossed with a tester strain. (J:127179)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ctsk (mouse)
Summary of all recombinase alleles driven by Ctsk.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsk Mutation:  31 strains or lines available
References
Original:  J:127179 Nakamura T, et al., Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007 Sep 7;130(5):811-23
All:  85 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory