Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm2(cre/ERT2)Brn
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Anton Berns
MGI ID:	MGI:3764519
Synonyms:	ERT2, Gt(ROSA)26Sortm2(cre/Esr1)Brn, Rosa26CreERT2, ROSA26-CreERT2
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm2(cre/ERT2)Brn page

Germline Transmission:	Earliest citation of germline transmission: J:127226
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gt(ROSA)26Sortm2(cre/ERT2)Brn expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gt(ROSA)26Sor (MGI:104735)   Mutation details: The endogenous locus was modified by insertion into the first intron of a construct containing the rabbit beta-globin 3' splice site followed by the cre/ERT2 fusion gene, which encodes Cre recombinase joined to a mutant hormone-binding domain of the human estrogen receptor that is activated by 4-hydroxytamoxifen (4-OHT), but not by the natural ER ligand 17-beta-estradiol. The fusion gene is followed by the rabbit beta-globin polyadenylation signal and a PGK-puro (puromycin resistance) cassette. Western blot analysis confirmed expression of the cre/ERT2 fusion product. (J:127226)

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm2(cre/ERT2)Brn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	993 strains or lines available

Original:	J:127226 Hameyer D, et al., Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues. Physiol Genomics. 2007 Sep 19;31(1):32-41
All:	104 reference(s)