Gdf3<Gt(AD0857)Wtsi> Gene trapped Allele Detail MGI Mouse (MGI:3764814)

Gdf3^{Gt(AD0857)Wtsi}
Gene trapped Allele Detail

Summary

Symbol:	Gdf3^{Gt(AD0857)Wtsi}
Name:	growth differentiation factor 3; gene trap AD0857, Wellcome Trust Sanger Institute
MGI ID:	MGI:3764814
Synonyms:	Gdf3^-
Gene:	Gdf3 Location: Chr6:122582362-122587046 bp, - strand Genetic Position: Chr6, 57.7 cM
Alliance:	Gdf3^{Gt(AD0857)Wtsi} page

Mutation
origin

Mutant Cell Line:	AD0857
Germline Transmission:	Earliest citation of germline transmission: J:127541
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector Vector: pGT0lxr

Mutation details: A genetrap vector consisting of a splice acceptor site and a single loxP site upstream of a frt flanked beta-geo cassette inserted into the only intron of the gene. No gene expression was detected in homozygous embryos or adult spleen tissue by RT-PCR. (J:127541)

Sequence Tags:

Sequence tag details (1 tag)

Genome Context:

Genome Browser view of this mutation

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Gdf3 Mutation:	40 strains or lines available

References

Original:	J:127541 Andersson O, et al., Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007 Nov 15;311(2):500-11
All:	2 reference(s)

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