Fasn<tm1Sem> Targeted Allele Detail MGI Mouse (MGI:3765070)

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Fasn^tm1Sem
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Fasn^tm1Sem
Name:	fatty acid synthase; targeted mutation 1, Clay F Semenkovich
MGI ID:	MGI:3765070
Synonyms:	Fas^f
Gene:	Fasn Location: Chr11:120696672-120715373 bp, - strand Genetic Position: Chr11, 84.56 cM
Alliance:	Fasn^tm1Sem page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:127793
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: A loxP flanked neo cassette was placed upstream of exon 4 and a third loxP site was placed downstream of exon 8. Insertion of targeting vector was verified by Southern blotting. (J:127793)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fasn Mutation:	89 strains or lines available

References

Original:	J:127793 Chakravarthy MV, et al., 'New' hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 2005 May;1(5):309-22
All:	33 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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