Chrna4tm2.1Dra
Targeted Allele Detail
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| Symbol: |
Chrna4tm2.1Dra |
| Name: |
cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 2.1, John Drago |
| MGI ID: |
MGI:3767042 |
| Synonyms: |
S248F |
| Gene: |
Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
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| Alliance: |
Chrna4tm2.1Dra page
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| Allele Type: |
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Targeted |
| Mutation: |
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Insertion
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Mutation details: In vivo Cre-mediated recombination removed the floxed neo cassette leaving just the S248F (TCG to TTT) in exon 5 in the putative M2 region. This mutation had little effect on nicotinic acetylcholine receptor ligand binding; however, dopamine release mediated by receptor complexes containing the mutated subunit was decreased at high agonist concentrations.
(J:125305)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Chrna4 Mutation: |
44 strains or lines available
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| Original: |
J:125305 Teper Y, et al., Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation. J Neurosci. 2007 Sep 19;27(38):10128-42 |
| All: |
1 reference(s) |
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Analysis Tools
