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Pitx2tm1Hmd
Targeted Allele Detail
Summary
Symbol: Pitx2tm1Hmd
Name: paired-like homeodomain transcription factor 2; targeted mutation 1, Hiroshi Hamada
MGI ID: MGI:3767234
Synonyms: Pitx2deltaASE
Gene: Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance: Pitx2tm1Hmd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:128475
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J X (C57BL/6 x C3H)F1
Mutation
description
Allele Type:    Targeted (Modified regulatory region)
Mutation:    Intragenic deletion
 
Mutation details: The 0.6 kb intronic enhancer (ASE) region was replaced with a neo cassette that was subsequently removed by cre-mediated recombination following electroporation of a CAG-cre vector. Deletion was confirmed by PCR. (J:128475)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  39 strains or lines available
References
Original:  J:128475 Shiratori H, et al., Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs. Development. 2006 Aug;133(15):3015-25
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory