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Tln1tm4.1Crit
Targeted Allele Detail
Summary
Symbol: Tln1tm4.1Crit
Name: talin 1; targeted mutation 4.1, David R Critchley
MGI ID: MGI:3770513
Synonyms: Tln1fl
Gene: Tln1  Location: Chr4:43531513-43562583 bp, - strand  Genetic Position: Chr4, 23.05 cM
Alliance: Tln1tm4.1Crit page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129707
Parent Cell Line:  E14.1a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Coding exons one through four (second through fifth exons) are flanked by loxP sites. This allele was generated by in vivo, Cre recombinase-mediated deletion of a loxP-flanked neomycin resistance cassette from the first intron of Tln1tm4Crit in cre transgenic embryos homozygous for the latter allele (personal communication). Talin expression can be ablated in specific cell/tissue types by crossing homozygous mice with appropriate cre transgenic mice. (J:129707)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tln1 Mutation:  147 strains or lines available
References
Original:  J:129707 Petrich BG, et al., Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007 Dec 24;204(13):3103-11
All:  45 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory