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Gene Expression Data
Assay Details
Assay
Reference: J:92284 Aijaz S, et al., Developmental expression profile of the optic atrophy gene product: OPA1 is not localized exclusively in the mammalian retinal ganglion cell layer. Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1667-73
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3770640
Gene symbol: Opa1
Gene name: OPA1, mitochondrial dynamin like GTPase
Antibody: anti-OPA1
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen Not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lens Absent There is no ocular expression.
Specimen 2B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: retina nuclear layer Weak Regionally restricted 2B Expression is in the prospective ganglion cell layer.
Specimen 2C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: neural retina Strong Regionally restricted 2C Expression is in the prospective ganglion cell layer and a low level of expression was also observed in the neuroblastic layer.
TS24: lens Strong 2C
TS24: eye Strong Regionally restricted 2C Expression is in the ectoderm overlying the eye.
Specimen 2D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: pigmented retinal epithelium Absent 2D
Specimen 2E: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: neural retina Very strong Regionally restricted 2E Expression is in the ganglion cell layer.
Specimen 2F: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: skeletal muscle Strong 2E Shown is a section of the skeletal muscle around the vertebrae.
Specimen Not shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: brain Strong
Specimen Not shown: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: brain Strong
TS25: heart Strong
TS25: liver Strong
TS25: lung Strong
TS25: skeletal muscle Strong
TS25: skin Strong
TS25: trunk Strong Regionally restricted Expression is in the somites.
Specimen 3A: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: retina ganglion cell layer Strong 3A
TS27: photoreceptor layer Absent 3A
TS27: pigmented retinal epithelium Absent 3A
TS27: retina inner nuclear layer Absent 3A
TS27: retina inner plexiform layer Absent 3A
TS27: retina outer nuclear layer Absent 3A
TS27: retina outer plexiform layer Absent 3A
Specimen 3B: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: optic nerve Strong 3B
TS27: retina ganglion cell layer Strong 3B
TS27: retina layer Strong Regionally restricted 3B Expression is in the optic fiber layer.
TS27: photoreceptor layer Absent 3B
TS27: pigmented retinal epithelium Absent 3B
TS27: retina inner nuclear layer Absent 3B
TS27: retina inner plexiform layer Absent 3B
TS27: retina outer nuclear layer Absent 3B
TS27: retina outer plexiform layer Absent 3B
Specimen 3C: postnatal day 2 (more )
Structure Level Pattern Image Note
TS27: retina ganglion cell layer Strong 3C
TS27: photoreceptor layer Absent 3C
TS27: pigmented retinal epithelium Absent 3C
TS27: retina inner nuclear layer Absent 3C
TS27: retina inner plexiform layer Absent 3C
TS27: retina outer nuclear layer Absent 3C
TS27: retina outer plexiform layer Absent 3C
Specimen 3D: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present Diffuse 3D
TS28: retina inner nuclear layer Present Diffuse 3D
TS28: retina inner plexiform layer Present Diffuse 3D
Specimen 3E: postnatal day 4 (more )
Structure Level Pattern Image Note
TS28: optic nerve Present 3E
Specimen 3F: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 3F
TS28: retina inner nuclear layer Present 3F
TS28: retina inner plexiform layer Present 3F
Specimen 3G: postnatal day 12 (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 3G
TS28: retina inner nuclear layer Present 3G
TS28: retina inner plexiform layer Present 3G
Specimen 4B: postnatal adult; Rpl24Bst/Rpl24+ (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 4B
TS28: retina inner plexiform layer Strong 4B
Specimen 4C: postnatal adult; Rpl24Bst/Rpl24+ (more )
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 4C Expression is in the region around the distortions.
Specimen 4D: postnatal adult; Rpl24Bst/Rpl24+ (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Strong 4D
TS28: retina inner plexiform layer Strong 4D
TS28: retina inner nuclear layer Weak 4D
Specimen Not shown: postnatal adult; Rpl24Bst/Rpl24+ (more )
Structure Level Pattern Image Note
TS28: lens Absent There is no expression in the lens or any other ocular tissue.
Specimen 4E: postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina ganglion cell layer Present 4E
TS28: retina inner nuclear layer Present 4E
TS28: retina inner plexiform layer Present 4E
TS28: retina outer plexiform layer Present 4E
Specimen 4F: postnatal adult (more )
Structure Level Pattern Image Note
TS28: optic nerve Weak Regionally restricted 4F Weak, patchy expression is observed in the myelinated region.
Specimen Not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: lens Absent There is no expression in the lens or any other ocular tissue.
TS28: liver Strong
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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06/12/2024
MGI 6.13 		The Jackson Laboratory