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Wnk4tm1Suc
Targeted Allele Detail
Summary
Symbol: Wnk4tm1Suc
Name: WNK lysine deficient protein kinase 4; targeted mutation 1, Shinichi Uchida
MGI ID: MGI:3771073
Synonyms: Wnk4D561A
Gene: Wnk4  Location: Chr11:101151393-101168235 bp, + strand  Genetic Position: Chr11, 64.51 cM
Alliance: Wnk4tm1Suc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129716
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation details: A nucleotide substitution leading to the amino acid substitution of alanine for aspartic acid at position 561 (D561A) was knocked into exon 7 along with a floxed neo cassette that was subsequently removed by cre-mediated recombination. (J:129716)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wnk4 Mutation:  58 strains or lines available
References
Original:  J:129716 Yang SS, et al., Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007 May;5(5):331-44
All:  11 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory