Ednratm2.1Hku
Targeted Allele Detail
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| Symbol: |
Ednratm2.1Hku |
| Name: |
endothelin receptor type A; targeted mutation 2.1, Hiroki Kurihara |
| MGI ID: |
MGI:3773698 |
| Synonyms: |
EdnralacZ, EdnralacZ1FRT |
| Gene: |
Ednra Location: Chr8:78389658-78451081 bp, - strand Genetic Position: Chr8, 36.63 cM, cytoband C2
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| Alliance: |
Ednratm2.1Hku page
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Comparison of craniofacial skeletons among E15.5 Ednratm2.1Hku/Ednratm2.1Hku (A), wild-type (B) and Ednratm6(Edn1)Hku/Ednra+ (C) mice
Show the 2 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:131382
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| Parent Cell Line: |
ATOM1 (ES Cell)
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| Strain of Origin: |
(C57BL/6 x 129)F1
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutation: |
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Insertion
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Mutation details: pCAGGS-FLPe was microinjected into fertilized eggs obtained from ICR females crossed to Ednratm2Hku/+ male mice. Transient expression of flp recombinase results in the removal of the puromycin resistance cassette. Expression of the lacZ gene was confirmed by beta-galactosidase assay.
(J:131382)
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Recombinase-mediated cassette exchange to generate the first-step targeted (Ednratm1Hku), lacZ-knocked-in (Ednratm2.1Hku), Edn1-knocked-in (Ednratm6(Edn1)Hku), and Hand2-knocked-in (Ednratm7(Hand2)Hku) alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ednra Mutation: |
35 strains or lines available
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| Original: |
J:131382 Sato T, et al., Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008 Feb;135(4):755-65 |
| All: |
7 reference(s) |
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Analysis Tools
