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Leprtm3(cre)Mgmj
Targeted Allele Detail
Summary
Symbol: Leprtm3(cre)Mgmj
Name: leptin receptor; targeted mutation 1, Martin G Myers, Jr
MGI ID: MGI:3773731
Synonyms: LeprCre
Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance: Leprtm3(cre)Mgmj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131433
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Leprtm3(cre)Mgmj expression driven by 1 gene
 
Mutation details: Exon 18b was replaced with an exon 18b followed by a stop codon and an IRES-cre-3'UTR-neo cassette. The functionality of this knock in was confirmed by crosses to report mice. (J:131433)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lepr (mouse)
Summary of all recombinase alleles driven by Lepr.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  122 strains or lines available
References
Original:  J:131433 Leshan RL, et al., Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring). 2006 Aug;14 Suppl 5:208S-212S
All:  68 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory