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Map1lc3btm1Mrab
Targeted Allele Detail
Summary
Symbol: Map1lc3btm1Mrab
Name: microtubule-associated protein 1 light chain 3 beta; targeted mutation 1, Marlene Rabinovtich
MGI ID: MGI:3774111
Synonyms: LC3B-
Gene: Map1lc3b  Location: Chr8:122317177-122325499 bp, + strand  Genetic Position: Chr8, 70.67 cM
Alliance: Map1lc3btm1Mrab page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130322
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The second amino acid encoded by exon 3 was replaced with a stop translation codon and the remainder of exon 3 and exon 4 were replaced with an IRES Tau-LacZ and neo cassette. The absence of endogenous protein product was confirmed on E14.5 head and trunk extracts and E18.5 head extracts. Beta-galactosidase is not expressed from this allele. (J:130322)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map1lc3b Mutation:  27 strains or lines available
Notes
ES cell line = CGR8.8 (subline of CGR8)
References
Original:  J:130322 Cann GM, et al., Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice. Dev Dyn. 2008 Jan;237(1):187-95
All:  24 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory