Polr1b<Gt(Ayu8019)Imeg> Gene trapped Allele Detail MGI Mouse (MGI:3774130)

Polr1b^{Gt(Ayu8019)Imeg}
Gene trapped Allele Detail

Summary

Symbol:	Polr1b^{Gt(Ayu8019)Imeg}
Name:	polymerase (RNA) I polypeptide B; gene trap Ayu8019, Institute of Molecular Embryology and Genetics
MGI ID:	MGI:3774130
Synonyms:	Rpo1-2^Gt
Gene:	Polr1b Location: Chr2:128942915-128968514 bp, + strand Genetic Position: Chr2, 62.68 cM, cytoband F3
Alliance:	Polr1b^{Gt(Ayu8019)Imeg} page

Mutation
origin

Mutant Cell Line:	Ayu8019
Germline Transmission:	Earliest citation of germline transmission: J:130226
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Gene trapped (Null/knockout, Reporter)
Mutation:		Insertion of gene trap vector
		Mutation details: The gene trap vector pU-Hachi (containing En-2 intron, splice acceptor and a floxed IRES-beta-geo cassette) was inserted 202 bp downstream of exon 14. The presence of the lacZ transcript was confirmed by northern blot analysis on brain, heart, kung, kindey and testis extracts. (J:130226)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Polr1b Mutation:	59 strains or lines available

References

Original:	J:130226 Chen H, et al., Early pre-implantation lethality in mice carrying truncated mutation in the RNA polymerase 1-2 gene. Biochem Biophys Res Commun. 2008 Jan 25;365(4):636-42
All:	2 reference(s)

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