Sqstm1<tm1Keta> Targeted Allele Detail MGI Mouse (MGI:3774352)

Sqstm1^tm1Keta
Targeted Allele Detail

Summary

Symbol:	Sqstm1^tm1Keta
Name:	sequestosome 1; targeted mutation 1, Keiji Tanaka
MGI ID:	MGI:3774352
Synonyms:	p62^-
Gene:	Sqstm1 Location: Chr11:50090193-50101654 bp, - strand Genetic Position: Chr11, 30.36 cM, cytoband B1.2
Alliance:	Sqstm1^tm1Keta page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:130839
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons 1-4 were replaced with a floxed neo cassette. The absence of transcript was confirmed by northern blot analysis on brain, heart, lung, liver and kidney extracts. (J:130839)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Sqstm1 Mutation:	35 strains or lines available

References

Original:	J:130839 Komatsu M, et al., Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell. 2007 Dec 14;131(6):1149-63
All:	49 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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