Gt(ROSA)26Sortm1(CAG-cre)Jphe
Targeted Allele Detail
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| Symbol: |
Gt(ROSA)26Sortm1(CAG-cre)Jphe |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jean-Paul Herman |
| MGI ID: |
MGI:3774388 |
| Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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| Alliance: |
Gt(ROSA)26Sortm1(CAG-cre)Jphe page
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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rapamycin |
| Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(CAG-cre)Jphe expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| chicken |
CAG |
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Mutation details: The expression of a dimerizable cre was achieved by insertion of the cre60.F2 N-terminal cre moiety which is fused to FRB (the ligand binding domain of FRAP,an FKBP12-rapamycin associated protein) under the control of the endogenous promoter and a Caggs-cre59.F2 cassette, containing the C-teminal moiety of cre fused to FKBP12 (FK506-binding protein) under control of the CAG promoter, into the ROSA locus. A hygro cassette was also inserted into the locus for selection purposes. The split cre is inactive until dimerization is induced by administration of rapamycin.
(J:130959)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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CAG
(chicken)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gt(ROSA)26Sor Mutation: |
1002 strains or lines available
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| Original: |
J:130959 Jullien N, et al., Conditional Transgenesis Using Dimerizable Cre (DiCre). PLoS One. 2007;2(12):e1355 |
| All: |
1 reference(s) |
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Analysis Tools
