Foxa2<tm2(cre/Esr1*)Moon> Targeted Allele Detail MGI Mouse (MGI:3774419)

Foxa2^{tm2(cre/Esr1*)Moon}
Targeted Allele Detail

Summary

Symbol:	Foxa2^{tm2(cre/Esr1*)Moon}
Name:	forkhead box A2; targeted mutation 2, Anna M Moon
MGI ID:	MGI:3774419
Synonyms:	Foxa2^mcm-neo, Foxa2^{tm2(cre/Esr1*)Moon}
Gene:	Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
Alliance:	Foxa2^{tm2(cre/Esr1*)Moon} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:130990
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Hypomorph, Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Foxa2^{tm2(cre/Esr1*)Moon} expression driven by 1 gene

Mutation details: An IRES followed by a mouse Esr1 binding domain fused to both sides of cre and an frt-flanked neo cassette was inserted in frame following the stop codon in exon 3. This allele is a hypomorph. (J:130990)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa2 (mouse) Summary of all recombinase alleles driven by Foxa2. Alliance mouse Foxa2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Foxa2 Mutation:	28 strains or lines available

References

Original:	J:130990 Park EJ, et al., System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice. Dev Dyn. 2008 Feb;237(2):447-53
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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