Atf2<tm3Nicj> Targeted Allele Detail MGI Mouse (MGI:3774771)

Atf2^tm3Nicj
Targeted Allele Detail

Summary

Symbol:	Atf2^tm3Nicj
Name:	activating transcription factor 2; targeted mutation 3, Nic Jones
MGI ID:	MGI:3774771
Synonyms:	ATF2^f
Gene:	Atf2 Location: Chr2:73646853-73722983 bp, - strand Genetic Position: Chr2, 43.86 cM
Alliance:	Atf2^tm3Nicj page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:123909
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Mutation details: Exons 8 and 9 encoding the DNA-binding domain and a portion of the leucine zipper were flanked by loxP sites. Gene expression was comparable to wild-type in numerous tissues. (J:131564)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Atf2^tm3Nicj

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Atf2 Mutation:	89 strains or lines available

References

Original:	J:123909 Breitwieser W, et al., Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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