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Relatm1Asba
Targeted Allele Detail
Summary
Symbol: Relatm1Asba
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, Albert S Baldwin
MGI ID: MGI:3775205
Synonyms: p65flox, RelAF
Gene: Rela  Location: Chr19:5687511-5698158 bp, + strand  Genetic Position: Chr19, 4.34 cM, cytoband B1-3
Alliance: Relatm1Asba page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flank neo cassette with a 5' loxP site was inserted downstream of exon 8 and an additional loxP site was inserted downstream of exon 4. In vitro flp-mediated recombination was used to remove the neo cassette leaving exons 5 through 8 floxed. (J:131977)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rela Mutation:  28 strains or lines available
References
Original:  J:131977 Steinbrecher KA, et al., Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J Immunol. 2008 Feb 15;180(4):2588-99
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory