Sp6<tm1Yoya> Targeted Allele Detail MGI Mouse (MGI:3775913)

Sp6^tm1Yoya
Targeted Allele Detail

Summary

Symbol:	Sp6^tm1Yoya
Name:	trans-acting transcription factor 6; targeted mutation 1, Yoshihiko Yamada
MGI ID:	MGI:3775913
Synonyms:	Epfn^-
Gene:	Sp6 Location: Chr11:96904395-96915565 bp, + strand Genetic Position: Chr11, 60.51 cM
Alliance:	Sp6^tm1Yoya page

Defective tooth formation in Sp6^tm1Yoya/Sp6^tm1Yoya mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:132157
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Exon 2, which contains the entire coding region, was replaced by a neo cassette. (J:132157)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	63 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Sp6 Mutation:	18 strains or lines available

References

Original:	J:132157 Nakamura T, et al., Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number. J Biol Chem. 2008 Feb 22;283(8):4825-33
All:	7 reference(s)

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