About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:132026 Farrington-Rock C, et al., Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Hum Mol Genet. 2008 Mar 1;17(5):631-41
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3776107
Gene symbol: Flnb
Gene name: filamin, beta
Reporter: lacZ
Direct Detection
Assay notes: Embryos were fixed in neutral-buffered formalin.
Results
Specimen Not shown: embryonic day 10.5; FlnbGt(RRF239)Byg/Flnb+ (more )
Structure Level Pattern Image Note
TS17: forelimb bud Present
TS17: head Present Regionally restricted Expression is present in the frontal and hind regions of the developing calvarium.
TS17: heart Present
Specimen 4A: embryonic day 12.5; FlnbGt(RRF239)Byg/Flnb+ (more )
Structure Level Pattern Image Note
TS21: skeleton Present 4A Expression is localized to the developing skeletal elements.
Specimen 4C: embryonic day 12.5; FlnbGt(RRF239)Byg/Flnb+ (more )
Note: Transverse section through the upper thorax and forelimb.
Structure Level Pattern Image Note
TS21: limb cartilage condensation Present 4C Expression is present in the pre cartilage primordia of the developing limbs.
TS21: forelimb digit Present 4C
TS21: humerus cartilage condensation Present 4C
TS21: radius-ulna cartilage condensation Present 4C
TS21: scapula pre-cartilage condensation Present 4C
Specimen 4D: embryonic day 12.5; FlnbGt(RRF239)Byg/Flnb+ (more )
Note: Transverse section through the trunk.
Structure Level Pattern Image Note
TS21: vertebral cartilage condensation Present Regionally restricted 4D Expression is present in the neural arch of the developing vertebrae.
TS21: rib cartilage condensation Present 4D
Specimen Not shown: embryonic day 12.5; FlnbGt(RRF239)Byg/Flnb+ (more )
Structure Level Pattern Image Note
TS21: cranium Present Regionally restricted Expression is present in the skull bones.
Specimen Not shown: embryonic day 14.5; FlnbGt(RRF239)Byg/Flnb+ (more )
Structure Level Pattern Image Note
TS22: skeleton Present At this age expression is localized to the skeletal elements.
TS22: humerus cartilage condensation Present Expression levels are reduced from those seen earlier.
TS22: rib cartilage condensation Present Expression levels are reduced from those seen earlier.
TS22: scapula cartilage condensation Present Expression levels are reduced from those seen earlier.
TS22: chondrocranium Absent There is no expression in the frontal calvarium.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory