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Leprtm2(cre)Rck
Targeted Allele Detail
Summary
Symbol: Leprtm2(cre)Rck
Name: leptin receptor; targeted mutation 2, Jeffrey M Friedman
MGI ID: MGI:3776158
Synonyms: LeprB-Cre, LepRbCre, LepRb-IRES-Cre, Leprcre, ObRb-Cre, Obrb-IRES-Cre
Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance: Leprtm2(cre)Rck page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68414
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Leprtm2(cre)Rck expression driven by 1 gene
 
Mutation details: A cre recombinase expression cassette containing an IRES domain and a FRT-flanked neomcyin cassette was placed immediately downstream of the stop codon for the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre expression in the hypothalamus was confirmed by use of a virus containing a cre-dependent reporter gene. (J:68414)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lepr (mouse)
Summary of all recombinase alleles driven by Lepr.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  122 strains or lines available
References
Original:  J:68414 DeFalco J, et al., Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science. 2001 Mar 30;291(5513):2608-13
All:  153 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory